JIFI (Jurnal Ilmiah Farmasi Imelda)

FORMULASI DAN UJI ANTIOKSIDAN SEDIAAN BODY SCRUB DARI EKSTRAK DAUN SRIKAYA (Annona squamosa L.) DENGAN METODE ABTS

Ucik Susilowati — 2026-04-01

HUBUNGAN TINGKAT KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP DAN OUTCOME TERAPI PASIEN DIABETES MELITUS TIPE 2 DI RSUD DR. MOEWARDI SURAKARTA

Neha Azziza Cherrysha Alifia — 2026-04-01

Type 2 Diabetes Mellitus is a chronic disease that requires long-term and continuous management. One of the key factors influencing treatment success is patient adherence to medication. Good adherence can improve quality of life and optimize therapeutic outcomes, while poor adherence often leads to unfavorable outcomes, such as uncontrolled HbA1c levels. This study aimed to determine the relationship between medication adherence and both quality of life and therapeutic outcomes among Type 2 Diabetes Mellitus patients at Dr. Moewardi General Hospital in Surakarta. This study employed an observational design with a cross-sectional approach. A total of 98 patients were recruited using purposive sampling. The instruments used included the MMAS-8 questionnaire to measure medication adherence, the WHOQOL-BREF questionnaire to assess quality of life, and laboratory HbA1c data to evaluate therapeutic outcomes. Data were analyzed using Pearson correlation and chi-square tests. The results showed that most patients had moderate adherence (64,3%), moderate quality of life (100%), and uncontrolled therapeutic outcomes. There was a significant relationship between medication adherence and quality of life (p = 0.015; r = -0.246), but no significant relationship between adherence and HbA1c therapeutic outcomes (p = 0.524). Other factors such as lifestyle, complications, and social support also influence therapeutic success.

PENGARUH JENIS PELARUT TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT KAYU RARU (Cotylelobium melanoxylon (Hook.f) Pierre) MELALUI UJI DPPH

Nurhadijah Sibagariang — 2026-04-01

FORMULASI DAN UJI MUTU FISIK SABUN PADAT MENGANDUNG EKSTRAK LAVENDER (Lavandula angustifolia Mill.) DAN KULIT BATANG KAYU MANIS (Cinnamomum burmanii)

Sri Rezeki Samosir — 2026-04-01

The manufacture of solid soap combination of lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii) has been carried out. The research method is experimental in the laboratory with a quantitative analysis approach. The sample of this research is from lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii). The research stages include making simplicia, evaporation extraction, phytochemical screening, making solid soap preparations and testing the physical quality of solid soap. The extraction stage uses the maceration method for 3 days with 96% ethanol solvent, the extract obtained using a rotary evaporator. Solid soap from a combination of lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii) is made in 3 formulations, namely 1%, 2%, 3%. Physical quality testing includes organoleptic test, pH test, foam height test, water content test. The results of the organoleptic test showed a brown colored preparation and a solid texture with a distinctive cinnamon aroma. The results of the pH test showed a pH of 11 for all three formulas. The results of the foam height test showed an initial foam height of 6cm – 7cm and a final foam height of the three formulas of 1cm. The results of the water content test at (F1) 1.29%, (F2) 1.03% and at (F3) 1.86%. The results of the study can be concluded that the combination of lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii) can be formulated as a solid soap preparation.

UJI AKTIVITAS ANTIOKSIDAN METODE DPPH DARI EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis L.) MENGGUNAKAN METODE MASERASI

Cindy Kurnia Sari — 2026-04-01

Breadfruit leaves (Artocarpus altilis L.) area plant with various health benefits due to their natural chemical compounds, one of which acts as an antioxidant. Antioxidants are compounds that can halt the oxidation process by donating electrons, there by protecting normal cells, fats, and proteins from damage caused by free radicals. The concentration of an antioxidant that causes a 50% reduction in DPPH activity is referred to as the IC₅₀. The objective of this study was to determine the effectiveness of ethanol extract from breadfruit leaves in combating oxidation using the DPPH method. The results showed an IC₅₀ value of 6.66 ppm for the extract, indicating very strong antioxidant activity, although it was more effective compared to vitamin C, which served as a positive control with an IC₅₀ value of 1.15 ppm. This difference in effectiveness is influenced by the amount of phenolic compounds present and the potential pro-oxidant effects at higher concentrations. In summary, breadfruit leaves have high potential as asource of natural antioxidants and can be used to develop pharmaceutical products to treat degenerative diseases.

IDENTIFIKASI ADVERSE DRUG REACTION (ADR) OBAT ANTI TUBERKULOSIS PADA PASIEN TB DI RSUD PASAR REBO JAKARTA TIMUR

Dini Permata Sari — 2026-04-01

Tuberculosis (TB) remains a major public health problem in Indonesia, ranking second globally in TB burden. Although Anti-Tuberculosis Drugs (ATDs) are effective in curing TB, prolonged treatment and combination regimens may lead to Adverse Drug Reactions (ADRs), potentially affecting patient adherence and treatment outcomes. This study aimed to identify the types of ADRs experienced by TB patients undergoing ATD therapy at Pasar Rebo General Hospital, East Jakarta, and to analyze the relationship between age, gender, and duration of drug use with ADR occurrence. This research employed a descriptive-analytic retrospective design conducted from June to July 2025. A total of 60 adult TB patients receiving first-line ATD therapy (Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol) were included. Data were collected using questionnaires and analyzed using univariate and multivariate statistical methods with SPSS. Causality assessment of ADRs was performed using the Naranjo algorithm. The results showed that 88.33% of patients experienced ADRs. The most frequently reported symptoms were nausea (48.33%), rash/itching (28.33%), and joint pain (26.67%). Most ADRs were categorized as “Probable” based on the Naranjo score. Multivariate analysis revealed that gender was significantly associated with ADR occurrence (p = 0.041), while age and duration of drug use were not statistically significant. In conclusion, ADRs are common among TB patients receiving ATD therapy, with gastrointestinal and dermatological symptoms being the most prevalent. Gender appears to be an important predictor of ADR risk. Therefore, close clinical monitoring and gender-sensitive pharmacovigilance strategies are essential to ensure patient safety, improve adherence, and optimize TB treatment outcomes.