JIFI (Jurnal Ilmiah Farmasi Imelda)

PENGARUH KUALITAS PELAYANAN DAN HARGA TERHADAP KEPUASAN PELANGGAN APOTEK CANGKIRAN

Nadia Anggi Lestari, Erki Arfianto, Ery Ardiyanti Ningtyas — Fri, 04 Oct 2024 09:05:16 +0000

Health is an important factor in life because with health, everyone is able to carry out activities smoothly without any interference (Kuniano, 2015). To support this health, health facilities are needed, one of which is a pharmacy. A pharmacy is one of the pharmaceutical service facilities as a place of practice for pharmacists. Pharmacy practitioners must know how to make pharmaceutical activities provide satisfaction and benefits for patients or consumers by providing complete drug information, comfortable facilities, communicating in easy-to-understand language, being able to understand consumer needs, appearing polite and courteous, friendly in conveying information, and providing fast and precise service to patients or consumers. Customer perceptions of prices, for example expensive, cheap or appropriate, have a strong influence on purchasing interest and purchase satisfaction (Herlina & Tugiono, 2021). The aim of the research was to ascertain how customer satisfaction at Cangkiran Pharmacy is impacted by pricing and service quality. However, it should be based on an Islamic perspective for pharmaceutical service activities to run with blessings and goodness. This research uses a quantitative approach method, which is a process of seeking knowledge with data in the form of numbers as a tool in analyzing information related to something to be known. Data is collected through the use of written questions (questionnaires).

INTERAKSI OBAT ANTIDIABETES DENGAN OBAT ANTITUBERKULOSIS (OAT) PADA PASIEN DIABETES MELLITUS TIPE 2 YANG TERINFEKSI TB PARU DI INSTALASI RAWAT INAP RUMAH SAKIT UMUM IMELDA PEKERJA INDONESIA MEDAN

Novycha Auliafendri, Alex Handani Sinaga, Kiki Restini Gea — Fri, 04 Oct 2024 09:05:40 +0000

Diabetes is a medical condition that can worsen the severity of pulmonary tuberculosis (TB) infection. Combining Antidiabetic Drugs with Antituberculosis Drugs (OAT) in type 2 DM patients who have pulmonary TB can cause undesirable pharmacological interactions. The aim of this study is to explain the relationship between Antidiabetic Drugs and OAT. The research design used in this study is a cross-sectional observational design, with a focus on descriptive statistical analysis. The research sample consisted of 72 patients. Data collection was carried out retrospectively using medical records and doctor's prescription forms. The Medscape (Drug Interactions Checker) tool was used for drug interaction analysis, while SPSS (Statistical Product and Service Solution) 21.0 for Windows was used for data processing. Research findings revealed that the occurrence of drug interactions between Antidiabetic Drugs and OAT varied based on gender characteristics, with 56.9% observed in men and 43.1% in women. Pharmacodynamic interactions reached 25.5% based on the mechanism of action, while pharmacokinetic interactions reached 5.7%. The remaining 68.9% were classified as unknown interactions. In contrast, minor types of drug interactions reached 68.9% in terms of severity, while moderate types of interactions reached 31.1%, and there were no significant interactions. This study concludes that the combination of antidiabetic drugs and OAT mainly causes pharmacological interactions both in the pharmacodynamic and pharmacokinetic pathways, with varying levels of severity, ranging from minimal to moderate.

FORMULASI SABUN CAIR ANTISEPTIK SARI AIR KULIT BUAH PISANG AMBON (MUSA PARADISIACA VAR SEPIENTUM L.) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP STAPHYLOCOCCUS AUREUS DAN ESCHERICHIA COLI

Muhammad Ramadani, Muhammad Gunawan, Enny Fitriani, Melati Yulia Kusumastuti — Fri, 04 Oct 2024 09:05:59 +0000

Cleanliness of the skin, hands and body is a state of being free of dirt, dust and microorganisms that can cause infection. The existence of these microorganisms can be overcome by using soap containing chemical compounds that have antibacterial activity. In the market there are many circulating antiseptic soaps containing synthetic antibacterials, but they often cause side effects, so it is necessary to make soaps containing natural antibacterials, for example, Ambon banana peel contains polyphenolic compounds and saponins have antibacterial activity. The study conducted a phytochemical screening of Ambon banana peels, made liquid soap containing water extract of Ambon banana peels as a cleanser and antibacterial and carried out antibacterial activity tests. Research stages: phytochemical screening of Ambon banana peel and water extract, liquid soap formulation containing 10%, 20% and 30% Ambon banana peel water extract (SKPA), evaluation of liquid soap including: stability, foam height, pH, irritation and preference test . Antibacterial activity test against Staphylococcus aureus, Escherichia coli and bacteria from volunteer hand washing water specimens. The results showed that the water extract from Ambon banana peel contains alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides, which can be formulated into liquid soap (SKPA) fulfilling the physical quality requirements. SKPA 30% liquid soap is the best because it is very liked by researchers, has strong antibacterial activity, diameter of inhibition against Staphylococcus aureus (17.23 ± 0.66) mm, and Escherichia coli (15.83 ± 0.66) mm. The total plate number for volunteer hand washing specimens, 10% SKPA resulted in a reduction of bacterial colonies of 49.78%, 30% SKPA obtained the greatest reduction in bacteria, namely 82.79, almost the same as Dettol liquid soap. What is circulating in the market is 83.02%.

GAMBARAN MEREK DAGANG DARI SEDIAAN SUNSCREEN YANG DIGUNAKAN SELURUH MAHASISWA PROGRAM STUDI DI UNIVERSITAS IMELDA MEDAN

Dea Aprian Dini, Dina Maya Syari, Mutiara Siahaan — Fri, 04 Oct 2024 09:06:22 +0000

Sun exposure can cause damage to the skin due to ultraviolet radiation. Skin needs special protection from ultraviolet rays, especially on skin organs, namely by using sunscreen. Sunscreen is a compound that functions to protect the skin from excessive exposure to ultraviolet rays. The type of research used is qualitative research using questionnaires to obtain student data. The population in this study was Imelda University Medan students at levels 1, 2, 3 and 4, totaling 1,333 people from 9 study programs. The data collection technique is using a questionnaire. The results of this research after data collection was carried out using a questionnaire and analyzed via SPSS, the results showed that there were 145 males at Imelda University in Medan who used sunscreen, while there were 715 females at Imelda University in Medan who used sunscreen, while sunscreen products the most popular one used by female students is Wardah 259 (19.4%). And the most popular product used by male students is Nivea Men 66 (4.9%). From this research it can be concluded that Wardah and Nivea Men products are the most popular at Imelda University Medan, and there are still many students who do not use sunscreen 473 (35.4%), consisting of male students 115 (8.6%) and 358 female students (26.8%), included in Imleda University, Medan. Even though sunscreen is really needed for the skin to protect it from ultraviolet rays.

PEMANFAATAN MORINGA OLIEFERA DAN ESSENTIAL OIL MENJADI MASKER PEEL OFF KESEHATAN KULIT WAJAH DENGAN KONSEP ECOFRIENDLY

Sri Rezeki Samosir, Jane Elnovreny, Hartika Samgryce Siagian, Ainun Mardiah — Fri, 04 Oct 2024 09:06:47 +0000

A peel-off mask cosmetic product has been made from the ethanol extract of the leaves of the Moringa oliefera plant. The research method is experimental. Moringa leaf extract was obtained by the maceration method using 75% ethanol solvent. The extract is divided into six formulations, namely FI (0.5%), FII (1%), FIII (1.5%) and FIV (0.5%), FV (1%), FVI (1.5%) . The formulation for making peel off mask products uses a mixture of green tea essential oils (FIV, FV, FVI). Evaluation of Peel Off mask product preparations consists of organoleptic tests, homogeneity tests, pH tests, Hedonic tests, Irritation tests, spreadability tests. Based on the results of organoleptic tests, non-essential oil preparations in FI have a yellow color, FII has a brown color, and FIII has a brown color, where all three formulations have the aroma of Moringa leaves, while the formulation with the addition of essential oil in FIV has a white color, FV has a brown color, and FVI Brown in color, all three formulations have the aroma of green tea essential oil. The homogeneity test results of all formulations have a homogeneous texture and have a pH of 7. The hedonic test uses 10 panelists to determine the panelists' level of preference. The hedonic test results for color are 40% FI, 50% FII, 60% FIII, 100% FIV, 90% FV and 90% FVI. The hedonic test for texture is 50% FI, 60% FII, 50% FIII, 80% FIV, 100% FV, and 90% FVI. The hedonic test for aroma obtained 20% FI, 40% FII, 50% FIII, 80% FIV, 90% FV and 90% FVI. The Moringa leaf extract peel off mask does not cause irritation to the skin and has a spreadability of around 3.9 – 6.2 cm.

IDENTIFIKASI STRUKTUR SENYAWA FLAVONOID DARI DAUN KESUM (Polygonum minus Huds.) MENGGUNAKAN METODE PEREAKSI GESER

Ita Inayah, Syumillah Saepudin, Humairo Mudrikah Ramdhani — Fri, 04 Oct 2024 09:07:14 +0000

Polygonum minus Huds atau tanaman kesum merupakan tanaman khas Kalimantan Barat. Kandungan metabolit sekunder pada tanaman ini yaitu fenol, terpenoid, alkaloid, flavonoid, saponin, dan tanin. Penelitian sebelumnya menunjukkan bahwa adanya isolat senyawa kimia golongan flavonoid. Dalam penelitian ini bertujuan untuk mengidentifikasi struktur senyawa flavonoid pada daun kesum menggunakan metode pereaksi geser. Ekstraksi dilakukan dengan cara maserasi menggunakan pelarut metanol selama 7x24 jam. Setelah itu, dilakukan skrining fitokimia menggunakan pereaksi Wilstater, H₂SO₄, dan NaOH 10%. Pemantauan ekstrak dilakukan menggunakan plat KLT dengan eluen n-heksan : etil asetat : asam asetat 98% (8 : 1 : 1). Kemudian dilakukan fraksinasi kromatografi cair vakum dengan eluen n-heksan (100%), n-heksan : etil asetat (50% : 50%), etil asetat (100%), etil asetat : metanol (50% : 50%), metanol (100%) dan kromatografi kolom dengan eluen n-heksan : etil asetat : asam asetat 98% (8 : 1 : 1). Tahap selanjutnya, isolasi menggunakan kromatografi lapis tipis preparatif dan dilakukan uji kemurnian dengan kromatografi lapis tipis dua dimensi. Identifikasi struktur senyawa flavonoid menggunakan pereaksi geser dilakukan dengan penambahan pereaksi geser seperti NaOH 2N, AlCl₃ 5%, NaOAc, NaOAc/H₃BO₃ dilakukan untuk menentukan kedudukan gugus hidroksil fenol bebas pada inti flavonoid. Berdasarkan hasil interpretasi menggunakan spektrofotometer UV-Vis (metode pereaksi geser) menunjukkan adanya flavonoid golongan flavonol (flavonoid 3-OH tersubstitusi). Berdasarkan teori kemotaksonomi, tumbuhan dalam satu famili umumnya mempunyai senyawa kimia yang serupa, sehingga kemungkinan mempunyai potensi yang serupa untuk pengobatan penyakit.

REVIEW ARTIKEL PENGARUH VARIASI KOSOLVEN TERHADAP STABILITAS SIRUP PARACETAMOL

Fri, 04 Oct 2024 09:07:50 +0000

The syrup is made with the aim of increasing patient acceptance in taking medicine because it is convenient and practical when consumed. Paracetamol is classified as a drug that is rather difficult to dissolve in water with a water solubility of 1: 70 so that in the formulation of syrups it is necessary to assist the dissolution process with several methods such as cosolvention and the addition of surfactants. This review article aims to analyze the studies that have been conducted related to the effect of cosolvent variations on the stability of paracetamol syrup preparation formulations. Several tests were conducted to evaluate the preparation of paracetamol syrup, namely organoleptic test, content determination test, pH test, viscosity test, and specific gravity test. Data was obtained from relevant literature sources such as Google Scholar, ResearchgateNet and Science direct and obtained 10 journals that met the criteria. The use of different cosolvents in syrup will produce different physical values. Paracetamol syrup with PEG 400 and glycerin cosolvents had greater viscosity than paracetamol syrup with propylene glycol and Ryoto sugar ester cosolvents. Paracetamol syrup with PEG 400 and glycerin cosolvents had a greater specific gravity than paracetamol syrup with propylene glycol cosolvents and Ryoto sugar ester surfactant. Based on the results of a review of 10 journal articles, it appears that the use of different cosolvents in paracetamol syrup preparations can modify the preparation and affect the level of stability of the resulting syrup preparation.

UJI POTENSI ANTITUBERKULOSIS EKSTRAK n-HEKSAN DAN EKSTRAK ETANOL DAUN RIMBANG (Solanum torvum Sw.) SECARA IN VITRO

Evi Harianti, Cut Fatimah, Muhammad Gunawan, Andi Lala — Sat, 05 Oct 2024 08:15:11 +0000

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis which still affects many Indonesians and causes death. Currently, many people are resistant to treating tuberculosis using synthetic chemicals, so many sufferers find it difficult to recover, while the discovery of new drugs is still rare, therefore we need drugs made from natural ingredients that have been used by the community to treat coughs with phlegm and blood, which is one of the Symptoms of tuberculosis include rimbang leaves (Solanum torvum Sw.). Therefore, researchers conducted antituberculosis potential tests with rimbang leaf extract (Solanum torvum Sw.) with the aim of obtaining alternative medicines from plants that are rational, safe, cheap and easy to obtain. The extract was made by percolation using n-hexane followed by ethanol fractionation, then a phytochemical screening test was carried out on fresh leaves, simplicia, ethanol extract and n-hexane extract. The antituberculosis test of n-hexane extract and ethanol extract was carried out on Mycobacterium tuberculosis bacteria using the Lowenstein-Jensen method using patient sputum which was first identified using Ziehl Nielsen staining. The results of the phytochemical screening test showed that the chemical compound groups in fresh leaves, simplicia, ethanol extract and n-hexane extract, namely ethanol extract, were positive for alkaloids, flavonoids, glycosides, saponins, steroids/triterpenoids. and tannins while the n-hexane extract was positive for glycosides and steroids/triterpenoids. The antituberculosis effectiveness of ethanol extract is stronger than n-hexane extract, because in the 1st week and 2nd week the ethanol extract was able to inhibit the growth of Mycobacterium tuberculosis, while the n-hexane extract from the 1st to the 4th week did not inhibit the growth of Mycobacterium tuberculosis at all.

UJI EFEKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK ETIL ASETAT DAUN RIMBANG (Solanum torvum Sw.) DAN DAUN KECOMBRANG (Etlingera elatior (Jack) R.M.sm.) TERHADAP Staphylococcus Aureus dan Escherichia Coli

Sri Rezeki Samosir, Hartika Siagian, Sefniarta Purba — Sat, 05 Oct 2024 08:17:10 +0000

The rimbang plant is one of the traditional plants used in the treatment of infectious diseases. The kecombrang plant has long been known and used by the public, several studies have shown that kecombrang flowers and leaves have antibacterial activity against gram-positive and gram-negative bacteria. To determine whether the combination of rimbang leaf extract and kecombrang leaf has antibacterial effectiveness against Staphylococcus aureus and Escherichia coli bacteria, use the disc method. Ethyl acetate extract of rimbang leaves and kecombrang leaves is made by maceration. The ethyl extract of rimbang leaves and kecombrang leaves was screened for phytochemical compounds. Antibacterial activity was tested using the paper disc diffusion method with varying concentrations of 30%, 40% and 50%. The results of screening for phytochemical compounds show that rimbang leaf extract contains alkaloids, terpenoids, flavonoids and tannins. Meanwhile, the results of screening for phytochemical compounds in kecombrang leaf extract contain alkaloids, saponins, flavonoids and tannins. The antibacterial effectiveness test of the combination of rimbang leaf and kecombrang leaf extracts from 3 concentration variations, namely 30%, 40% and 50%, has antibacterial effectiveness against staphylococcus aureus and Escherichia coli, the most effective concentration for staphylococcus aureus bacteria is at a concentration of 30% with a ratio of 3 :1 with a result of (13.2) while Escherichia coli bacteria were found at a concentration of 30% with a ratio of 1:3 with a result of (10.3). The combination of ethyl acetate extract of rimbang leaves (Solanum torvum Sw.) and kecombrang leaves (Etlingera elatior (Jack) R.M.sm.) has been proven to have antibacterial effectiveness against Staphylococcus aureus and Escherichia coli bacteria. Based on the one way ANOVA data analysis test, there is a significant difference in antibacterial inhibition power.