JIFI (Jurnal Ilmiah Farmasi Imelda)

FORMULASI DAN UJI ANTIOKSIDAN SEDIAAN BODY SCRUB DARI EKSTRAK DAUN SRIKAYA (Annona squamosa L.) DENGAN METODE ABTS

Ucik Susilowati, Tiara Ajeng Listyani, Danang Raharjo — Wed, 01 Apr 2026 00:00:00 +0000

HUBUNGAN TINGKAT KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP DAN OUTCOME TERAPI PASIEN DIABETES MELITUS TIPE 2 DI RSUD DR. MOEWARDI SURAKARTA

Neha Azziza Cherrysha Alifia, Kharisma Jayak Pratama, Anna Fitriawati — Wed, 01 Apr 2026 00:00:00 +0000

Type 2 Diabetes Mellitus is a chronic disease that requires long-term and continuous management. One of the key factors influencing treatment success is patient adherence to medication. Good adherence can improve quality of life and optimize therapeutic outcomes, while poor adherence often leads to unfavorable outcomes, such as uncontrolled HbA1c levels. This study aimed to determine the relationship between medication adherence and both quality of life and therapeutic outcomes among Type 2 Diabetes Mellitus patients at Dr. Moewardi General Hospital in Surakarta. This study employed an observational design with a cross-sectional approach. A total of 98 patients were recruited using purposive sampling. The instruments used included the MMAS-8 questionnaire to measure medication adherence, the WHOQOL-BREF questionnaire to assess quality of life, and laboratory HbA1c data to evaluate therapeutic outcomes. Data were analyzed using Pearson correlation and chi-square tests. The results showed that most patients had moderate adherence (64,3%), moderate quality of life (100%), and uncontrolled therapeutic outcomes. There was a significant relationship between medication adherence and quality of life (p = 0.015; r = -0.246), but no significant relationship between adherence and HbA1c therapeutic outcomes (p = 0.524). Other factors such as lifestyle, complications, and social support also influence therapeutic success.

PENGARUH JENIS PELARUT TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT KAYU RARU (Cotylelobium melanoxylon (Hook.f) Pierre) MELALUI UJI DPPH

Nurhadijah Sibagariang, Roy Indrianto Bangar, Refi Ikhtiari — Wed, 01 Apr 2026 00:00:00 +0000

FORMULASI DAN UJI MUTU FISIK SABUN PADAT MENGANDUNG EKSTRAK LAVENDER (Lavandula angustifolia Mill.) DAN KULIT BATANG KAYU MANIS (Cinnamomum burmanii)

Sri Rezeki Samosir, Dina Maya Syari, Mawarni Atika Sari — Wed, 01 Apr 2026 00:00:00 +0000

The manufacture of solid soap combination of lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii) has been carried out. The research method is experimental in the laboratory with a quantitative analysis approach. The sample of this research is from lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii). The research stages include making simplicia, evaporation extraction, phytochemical screening, making solid soap preparations and testing the physical quality of solid soap. The extraction stage uses the maceration method for 3 days with 96% ethanol solvent, the extract obtained using a rotary evaporator. Solid soap from a combination of lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii) is made in 3 formulations, namely 1%, 2%, 3%. Physical quality testing includes organoleptic test, pH test, foam height test, water content test. The results of the organoleptic test showed a brown colored preparation and a solid texture with a distinctive cinnamon aroma. The results of the pH test showed a pH of 11 for all three formulas. The results of the foam height test showed an initial foam height of 6cm – 7cm and a final foam height of the three formulas of 1cm. The results of the water content test at (F1) 1.29%, (F2) 1.03% and at (F3) 1.86%. The results of the study can be concluded that the combination of lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii) can be formulated as a solid soap preparation.

UJI AKTIVITAS ANTIOKSIDAN METODE DPPH DARI EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis L.) MENGGUNAKAN METODE MASERASI

Cindy Kurnia Sari, Razoki Razoki, Erida Novriani — Wed, 01 Apr 2026 00:00:00 +0000

Breadfruit leaves (Artocarpus altilis L.) area plant with various health benefits due to their natural chemical compounds, one of which acts as an antioxidant. Antioxidants are compounds that can halt the oxidation process by donating electrons, there by protecting normal cells, fats, and proteins from damage caused by free radicals. The concentration of an antioxidant that causes a 50% reduction in DPPH activity is referred to as the IC₅₀. The objective of this study was to determine the effectiveness of ethanol extract from breadfruit leaves in combating oxidation using the DPPH method. The results showed an IC₅₀ value of 6.66 ppm for the extract, indicating very strong antioxidant activity, although it was more effective compared to vitamin C, which served as a positive control with an IC₅₀ value of 1.15 ppm. This difference in effectiveness is influenced by the amount of phenolic compounds present and the potential pro-oxidant effects at higher concentrations. In summary, breadfruit leaves have high potential as asource of natural antioxidants and can be used to develop pharmaceutical products to treat degenerative diseases.

IDENTIFIKASI ADVERSE DRUG REACTION (ADR) OBAT ANTI TUBERKULOSIS PADA PASIEN TB DI RSUD PASAR REBO JAKARTA TIMUR

Dini Permata Sari, Julita Silitonga, Farisa Luthfiana, Ria Anggraeni — Wed, 01 Apr 2026 00:00:00 +0000

Tuberculosis (TB) remains a major public health problem in Indonesia, ranking second globally in TB burden. Although Anti-Tuberculosis Drugs (ATDs) are effective in curing TB, prolonged treatment and combination regimens may lead to Adverse Drug Reactions (ADRs), potentially affecting patient adherence and treatment outcomes. This study aimed to identify the types of ADRs experienced by TB patients undergoing ATD therapy at Pasar Rebo General Hospital, East Jakarta, and to analyze the relationship between age, gender, and duration of drug use with ADR occurrence. This research employed a descriptive-analytic retrospective design conducted from June to July 2025. A total of 60 adult TB patients receiving first-line ATD therapy (Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol) were included. Data were collected using questionnaires and analyzed using univariate and multivariate statistical methods with SPSS. Causality assessment of ADRs was performed using the Naranjo algorithm. The results showed that 88.33% of patients experienced ADRs. The most frequently reported symptoms were nausea (48.33%), rash/itching (28.33%), and joint pain (26.67%). Most ADRs were categorized as “Probable” based on the Naranjo score. Multivariate analysis revealed that gender was significantly associated with ADR occurrence (p = 0.041), while age and duration of drug use were not statistically significant. In conclusion, ADRs are common among TB patients receiving ATD therapy, with gastrointestinal and dermatological symptoms being the most prevalent. Gender appears to be an important predictor of ADR risk. Therefore, close clinical monitoring and gender-sensitive pharmacovigilance strategies are essential to ensure patient safety, improve adherence, and optimize TB treatment outcomes.

EVALUASI FORMULASI SEDIAAN MIKROENKAPSULASI EKSTRAK ETANOL DAUN MINDI (Melia Azedarach L.)

Casey Dola Rebeca br Pinem, Razoki Razoki, Erida Novriani — Thu, 02 Apr 2026 00:00:00 +0000

Microencapsulation is a technology used to protect active ingredients from environmental influences and enhance their stability. This study aimed to evaluate the formulation of microencapsulated ethanol extract of mindi leaves (Melia azedarach L.), which possesses pharmacological activities as an antioxidant, antibacterial, and antidiabetic agent. The extraction of mindi leaves was performed using the maceration method with 80% ethanol, yielding a 10.4% extract. Microencapsulation was prepared using sodium alginate and chitosan as coating materials, with three different extract concentrations (0.25%, 0.5%, and 0.75%). Formulation evaluation included moisture content testing, stability testing using cycling test, and floating test on rat gastric mucosa. The results showed that moisture content ranged from 0.37% to 0.63%, with the 0.75% formulation having the lowest moisture content (0.37%). Stability testing over six cycles demonstrated that all formulations remained stable without significant changes in color, texture, and shape. The floating test showed a lag time of less than 2 minutes for all formulations with floating time ranging from 3 to 6 hours, where the 0.25% concentration exhibited the longest floating time (6 hours). It can be concluded that microencapsulation technology successfully produced mindi leaf ethanol extract preparations with stable characteristics, low moisture content, and good floating capability, making it potential as an oral drug delivery system.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN SELEDRI (Apium graveolens L) TERHADAP BAKTERI PSEUDOMONAS AERUGINOSA SECARA IN VITRO

Wahyuni Sihombing, Muhammad Yunus, Edy Fachrial — Sat, 11 Apr 2026 00:00:00 +0000

Celery leaves (Apium graveolens L) are plants with various properties according to people's beliefs, one of which is functioning as an antibacterial for skin infections. The skin on the largest human body organ located on the external part of the body whose function is to protect the body parts underneath. This skin disease is caused by bacteria, namely Pseudomonas aeruginosa bacteria, this bacteria is a gram-negative bacteria. The purpose of this study was to determine the effectiveness of celery leaves (Apium graveolens L) against pseudomonas aeruginosa bacteria In Vitro, with concentrations of 2.5%, 5%, 7.5%, 10%, 15%, 20%. In the negative control using 10% DMSO solution, and in the positive control using chloramphenicol disk This study is an experimental study. The research method uses the maceration method using 96% ethanol solvent, sterilization of tools, bacterial rejuvenation, media preparation, test solution preparation, and measurement of inhibition zones after incubation for 24 hours at 37 ° C. The results of this study showed that celery leaf extract (Apium graveolens L.) could inhibit bacterial growth at all tested concentrations. The conclusion is that celery leaf extract (Apium graveolens L) is effective in inhibiting bacterial growth.